TREX Indexing: activating failed with user has no permission

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Symptom
Activating message indexing with TREX from the Index Administration UI in Runtime Workbench fails for the Adapter Engine. The error message states that the user has no permissions, although he is assigned to all relevent user roles (roles with modify and administration rights like SAP_XI_ADMINISTRATOR, SAP_XI_CONFIGURATOR, SAP_XI_MONITOR,…).
The error can appear in [...]

Enhancements:Poor performance when saving/activating program

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Symptom
Activating a program containing implicit enhancements can last from 5-10 minutes
Other terms
Where used list Index generation, Performance, Activation
Reason and Prerequisites
When activating a program contining enhancements, the program used to generate index for where used list ‘RS_NEW_PROGRAM_INDEX’ is called many times.This can cause performance problems during activation.
Solution
Please apply corrections indicated in this note